Maintenance Chemotherapy for Patients with Rhabdomyosarcoma

Bisogno G, Minard-Colin V, Jenney M, Ferrari A, Chisholm J, Di Carlo D, Hjalgrim LL, Orbach D, Merks JHM, Casanova M. Cancers (Basel). 2023 Aug 7;15(15):4012. doi: 10.3390/cancers15154012.

The updated results of the RMS2005 randomized study confirm that patients with non-metastatic high…

Outcomes in lung-only metastatic rhabdomyosarcoma: An analysis of data from the European paediatric Soft tissue sarcoma Study Group MTS 2008 study

Chisholm JC, Schoot RA, Cameron AL, Casanova M, Minard-Colin V, Coppadoro B, Garrido B, Rogers B, Orbach D, Glosli H, Ben-Arush M, Ferman S, Scarzello G, van Rijn RR, Hladun R, Corradini N, Ferrari A, Jenney M, Bisogno G, Merks JHM. EJC 2023.

Time to broaden the eligibility criteria in paediatric oncology trials? An analysis of patients with rhabdomyosarcoma non-eligible to the EpSSG RMS2005 trial

Bisogno G, De Salvo GL, Minard-Colin V, Davila Fajardo R, Coppadoro B, Jenney M, Ferrari A, Hladun Alvaro R, Dall’Igna P, Glosli H, Merks JHM. EJC. 2023 May doi:

Outcome of patients with undifferentiated embryonal sarcoma of the liver treated according to European soft tissue sarcoma protocols

Guérin F, Martelli H, Rogers T, Zanetti I, Terwisscha van Scheltinga S, De Corti F, Guillen Burrieza G, Minard-Colin V, Orbach D, van Noesel MM, Karanian M, Dávila Fajardo R, Merks JHM, Ferrari A, Bisogno G, Pediatr Blood Cancer. 2023 Jul;70(7):e30374. doi: 10.1002/pbc.30374. Epub 2023 Apr 21.

Highlights of the paper: Neoadjuvant chemotherapy for pediatric patients with UESL increases the…

Nonmetastatic Rhabdomyosarcoma in Children and Adolescents: Overall Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS2005 Study

Bisogno G, Minard-Colin V, Zanetti I, Ferrari A, Gallego S, Davila Fajardo R, Mandeville H, Kelsey A, Alaggio R, Orbach D, Terwisscha van Scheltinga S, Guillen Burrieza G, Ben-Arush M, Glosli H, Mudry P, Ferman S, Devalck C, Defachelles AS, Merks JHM, Jenney M.
J Clin Oncol 2023 May 1;41(13):2342-2349.doi: 10.1200/JCO.22.02093. Epub 2023 Feb 27.

The study was open from October 1st, 2005, to December 31st, 2016 and 1,733 patients were enrolled…

Intra-abdominal desmoplastic small round cell tumor: The European pediatric Soft tissue sarcoma Study Group (EpSSG) experience.

Berlanga P, Orbach D, Schoot RA, Casanova M, Alaggio R, Corradini N, Brennan B, Ramirez-Villar GL, Hjalgrim L, Chisholm J, Bisogno G, Coppadoro B, Safwat A, Merks JHM, Guillen Burrieza G, van Noesel MM, Ferrari A.Pediatr Blood Cancer 2023 May 26;e30447. doi: 10.1002/pbc.30447.

Desmoplastic small round cell tumor (DSRCT) is an ultra-rare and aggressive mesenchymal tumor…

Metastatic adult-type non-rhabdomyosarcoma soft tissue sarcomas in children and adolescents: A cohort study from the European paediatric Soft tissue sarcoma Study Group.

Ferrari A, Orbach D, Casanova D, van Noesel MM, Berlanga P, Brennan B, Corradini N, Schoot RA, Ramirez-Villar GA, Hjalgrim LL, Alaggio R, Guillen Burrieza G, Safwat A, Cameron A, van Rijn RR, Minard-Colin V, Zanetti I, Bisogno G, Chisholm J, Merks JHM. Cancer 2023 Apr 21. doi: 10.1002/cncr.34814. Online ahead of print

Pediatric non-rhabdomyosarcoma soft tissue sarcomas form a heterogeneous group of rare tumors. While…

The significance of margins in pediatric Non-Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)

Sparber-Sauer M, Ferrari A, Spunt SL, Vokuhl C, Casey D, Lautz TB, Meyer WH, Walterhouse DO, Pajtler KW, Alaggio R, Schmidt A, Safwat A, Timmermann B, Dall'Igna P, Chen S, Weiss AR, Orbach D.
Pediatr Blood Cancer 2023 Feb;70(2):e30116. doi: 10.1002/pbc.30116. Epub 2022 Nov 28, 2023 Feb 6. doi: 10.1002/cam4.5671. Online ahead of print.

Margin status following surgery in children, adolescents and young adults with soft tissue sarcomas…

Malignant ectomesenchymoma in children: The European pediatric Soft tissue sarcoma Study Group experience

Milano GM, Orbach D, Casanova M, Berlanga P, Schoot R, Corradini N, Brennan B, Ramirez-Villar G, Lyngsie Hjalgrim L, van Noesel M, Alaggio R, Ferrari A
Pediatr Blood Cancer 2023 Feb;70(2):e30116. doi: 10.1002/pbc.30116. Epub 2022 Nov 28

This is a short report on 10 cases of malignant ectomesenchymoma (MEM) enrolled in the EpSSG NRSTS…

Metastatic rhabdomyosarcoma with exclusive distant lymph node involvement: A European Pediatric Soft tissue sarcoma Study Group (EpSSG) report

Mercolini F, Merks JHM, Minard-Colin V, Cameron A, Terwisscha van Scheltinga S, Sher O, Fichera G, Orbach D, Glosli H, Coppadoro B, Gallego S, Chisholm J, Bisogno G. Pediatr Blood Cancer
. 2023 Mar;70(3):e30143. doi: 10.1002/pbc.30143.

Prognosis of patients with metastatic rhabdomyosarcoma is still poor. However, efforts must be made…

Rhabdomyosarcoma with unknown primary tumor site: A report from European pediatric Sift tissue sarcoma Study Group (EpSSG)

Affinita MC, Merks JHM, Chisholm JC, Haouy S, Rome A, Rabusin M, Brennan B, Bisogno G. Pediatr Blood Cancer. 2022 Sep 12:e29967. doi: 10.1002/pbc.29967. Online ahead of print.

Abstract Background: Rhabdomyosarcoma (RMS) is an aggressive malignancy, and 20% of children present…

Epithelioid hemangioendothelioma in Children: the European pediatric soft tissue sarcoma study group (EpSSG) Experience

Orbach D, van Noesel MM, Brennan B, Corradini N, Alaggio R, Ben Arush M, Schoot RA, Berlanga P, Zanetti I, Lyngsie Hjalgrim L, De Corti F, Ramirez G, Casanova M, Ferrari A. Pediatr Blood Cancer 2022 Jul 16;e29882. doi: 10.1002/pbc.29882. Online ahead of print.

Abstract The European pediatric Soft tissue sarcoma Study Group analyzed all children with…

Therapy and Prognostic Significance of Regional Lymph node involvement in Embryonal Rhabdomyosarcoma: a Report from the European paediatric Soft tissue Sarcoma Study Group

Ben Arush M, Minard-Colin V, Scarzello G, Davila Fajardo, R, Terwisscha Van Scheltinga S, Bernier-Chastagner V, Jenney M, Gallego S, Zanetti I, Česen M, Merks JHM, G. Bisogno European Journal of Cancer Eur J Cancer 2022 Jun 25;172:119-129. doi: 10.1016/j.ejca.2022.05.033. Online ahead of print

Abstract Purpose: Regional lymph node disease (N1) is a component of the risk-based treatment…

Congenital spindle cell rhabdomyosarcoma: An international cooperative analysis.

Whittle S, Venkatramani R, Schönstein A, D Pack S, Alaggio R, Vokuhl C, Rudzinski ER, Wulf AL, Zin A, Gruver JR, Arnold MA, Merks JHM, Hettmer S, Koscielniak E, Barr FG, Hawkins DS, Bisogno G, Sparber-Sauer M. Eur J Cancer 2022 Jun;168:56-64. doi: 10.1016/j.ejca.2022.03.022. Epub 2022 Apr 19.

Abstract Background: Spindle cell rhabdomyosarcoma (RMS) is a rare variant of RMS accounting for up…

Metastatic Rhabdomyosarcoma: Results of the European Paediatric Soft Tissue Sarcoma Study Group MTS 2008 Study and Pooled Analysis With the Concurrent BERNIE Study.

Schoot RA, Chisholm JC, Casanova M, Minard-Colin V, Geoerger B, Cameron AL, Coppadoro B, Zanetti I, Orbach D, Kelsey A, Rogers T, Guizani C, Elze M, Ben-Arush M, McHugh K, van Rijn RR, Ferman S, Gallego S, Ferrari A, Jenney M, Bisogno G, Merks JHM J Clin Oncol. 2022 Jun 16:JCO2102981. doi: 10.1200/JCO.21.02981. Online ahead of print.PMID: 35709412

Abstract Purpose: Outcome for patients with metastatic rhabdomyosarcoma (RMS) is poor. This study…

Adolescents and young adults with rhabdomyosarcoma treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) protocols: a cohort study.

Ferrari A, Chisholm J, Jenney M, Minard-Colin V, Orbach D, Casanova M, Guillen G, Glosli H, van Rijn RR, Schoot RA, Cameron AL, Rogers T, Alaggio R, Ben-Arush M, Mandeville HC, Devalck C, Defachelles AS, Coppadoro B, Bisogno G, Merks JHM. Lancet Child Adolesc Health. 2022 Jun 8;S2352-4642(22)00121-3. doi: 10.1016/S2352-4642(22)00121-3. Online ahead of print.

Abstract Background: Adolescent and young adult patients with rhabdomyosarcoma often have poorer…

Perianal/perineal rhabdomyosarcoma: results of the SIOP MMT-95, ITALIAN RMS-96, and EpSSG RMS-2005 studies

Rogers T, Zanetti I, Coppadoro B, Martelli H, Jenney M, Minard-Colin V, Terwisscha van Scheltinga SEJ, Skerritt C, Dávila Fajardo R, Guérin F, Kelsey A, Merks JHM, Mandeville H, Guillén G, Glosli H, Bisogno G. Pediatr Blood Cancer 2022 Apr 23;e29739. doi: 10.1002/pbc.29739. Online ahead of print.

Abstract Background/objectives: Rhabdomyosarcoma of the perianal/perineal region (PRMS) is rare,…

In transit metastases in children, adolescents and young adults with localized rhabdomyosarcoma of the distal extremities: Analysis of the EpSSG RMS 2005 study.

Terwisscha van Scheltinga CEJ, Wijnen MHWA, Martelli H, Guerin F, Rogers T, Craigie RJ, Guillén Burrieza G, Dall'Igna P, De Corti F, Smeulders N, van Rijn RR, Dávila Fajardo R, Mandeville HC, Zanetti I, Coppadoro B, Minard-Colin V, Jenney M, Bisogno G, van Noesel MM, van der Steeg AFW, Merks JHM. European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Follow journal, doi: 10.1016/j.ejso.2022.03.001

Abstract In-transit metastases (ITM) are defined as metastatic lymph nodes or deposits occurring…

Localised rhabdomyosarcoma in infants (< 12 months) and young children (12-36 months of age) treated on the EpSSG RMS 2005 study

Slater O, Gains J, Kelsey A, De Corti F, Zanetti I, Coppadoro B, Jorgensen M, Gallego S, Orbach D, Glosli H, Cesen M, Gaze MN, Smeulders N, Ferrari A, Jenney M, Minard-Colin V, Bisogno G, .Merks JHM for the European paediatric Soft tissue sarcoma Study Group Eur J Cancer. 2022 Jan;160:206-214. doi: 10.1016/j.ejca.2021.10.031. Epub 2021 Dec 2.

Abstract Background: Infants (<12 months) with rhabdomyosarcoma have historically had poorer outcome…

Congenital rhabdomyosarcoma: A report from the European paediatric Soft tissue sarcoma Study Group

Bisogno G, Minard-Colin V, Arush MB, Daragjati J, Coppadoro B, Gallego S, Alaggio R, Smeulders N, Mudry P, Zin A, Merks JHM, Slater O. Pediatr Blood Cancer. 2021 Sep 28:e29376. doi: 10.1002/pbc.29376.

Abstract Procedure Congenital rhabdomyosarcoma (RMS) represents a challenging disease due to its…