Impact of Centres With Different Patient Volume on Diagnostic Process, Therapeutic Strategy and Outcome in Patients With Localised Rhabdomyosarcoma: A Report From the European paediatric Soft tissue sarcoma Study Group (EpSSG).
Affinita MC, Cesen M, Mudry P, Devalck C, Glosli H, Coppadoro B, Zanetti I, Minard-Colin V, Chisholm JC, Orbach D, Terwisscha van Scheltinga S, Fajardo RD, Borgwardt L, Merks JHM, Bisogno G. Pediatr Blood Cancer. 2026 Jul;73(7):e70373. doi: 10.1002/1545-5017.70373. Epub 2026 May 5.PMID: 42084148
Children with rhabdomyosarcoma (RMS) are treated at hospitals that care for different numbers of…
Surgical nodal staging in rhabdomyosarcoma of the bladder and/or prostate with or without nodal or metastatic spread. A report from the European Paediatric Soft-Tissue Sarcoma Study Group (EpSSG).
Smeulders N, Gaze MN, Guérin F, Rogers T, Terwisscha van Scheltinga S, DeCorti F, Chisholm J, Slater O, Minard-Colin V, Coppadoro B, Zanetti I, Craigie R, Burrieza GG, Dall'Igna P, Fajardo RD, Lim P, Chargari C, Espenel S, Luis Huertas AL, Cho A, Nguyen T, Rees H, Bisogno G, Merks JHM, Martelli H.
J Pediatr Surg. 2026 Jul;61(7):163162. doi: 10.1016/j.jpedsurg.2026.163162. Epub 2026 Apr 27.PMID: 42055245
Children with bladder or prostate rhabdomyosarcoma (BP-RMS) need careful staging to determine…
Local therapy for rhabdomyosarcoma of the bladder and/or prostate without nodal or metastatic spread during the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 study
Smeulders N, Guerin F, Gaze MN, Rogers T, Terwisscha van Scheltinga S, De Corti F, Chisholm J, Slater O, Minard-Colin V, Coppadoro B, Zanetti I, Craigie R, Guillen Burrieza G, Dall'Igna P, Davila Fajardo R, Lim PS, Chargari C, Espenel S, Huertas AL, Cho A, Nguyen T, Rees H, Bisogno G, Merks JHM, Martelli H. JC Paediatric Oncology 6 (2025) 100313 https://doi.org/10.1016/j.ejcped.2025.100313
This study looked at children and young people with a rare cancer called bladder-prostate…
Surgical Lymph Node Staging in Extremity Rhabdomyosarcoma: The EpSSG RMS 2005 Trial Experience.
Terwisscha van Scheltinga S, Merks JHM, Guerin F, Rogers T, Craigie RJ, Guillén G, De Corti F, Dall'Igna P, Dávila Fajardo R, Bisogno G, Ferrari A, Orbach D, Jenney M, Chisholm JC, Minard-Colin V, Cesen M, Jehanno N, Hiemcke-Jiwa LS, Zanetti I, Coppadoro B, van der Steeg AFW, van Noesel MM, Wijnen MHWA.
Ann Surg Oncol. 2025 Jul 24. doi: 10.1245/s10434-025-17908-3. Online ahead of print. PMID: 40705262
Early radiologic tumour volume response in non-metastatic rhabdomyosarcoma is not predictive for survival.
de Vries ISA, Morosi C, Bisogno G, Minard-Colin V, Coppadoro B, Zanetti I, Ferrari A, Orbach D, Moalla S, Ben-Arush M, Devalck C, van Ewijk R, McHugh K, Jenney M, Chisholm J, Guillen G, Mandeville H, Merks JHM, Van Rijn RR
Pediatr Radiol. 2025 Sep;55(10):2160-2170. doi: 10.1007/s00247-025-06359-3. Epub 2025 Aug 14.PMID: 40810863
Children with rhabdomyosarcoma usually have imaging scans during chemotherapy to see whether their…
Maintenance Chemotherapy in Patients With High-Risk Rhabdomyosarcoma: Long-Term Survival Analysis of the European Paediatric Soft Tissue Sarcoma Study Group RMS
2005 Trial
Bisogno G, Chisholm J, Hladun R, De Salvo GL, Guerin F, Casanova M, Mandeville H, Alaggio R, Coppadoro B, Orbach D, Ferrari A, van Rijn R, Defachelles AS, Ben-Arush M, Glosli H, Cesen M, Merks JHM, and Minard-Colin V. J Clin Oncol. 2025 Mar 7:JCO2402850. doi: 10.1200/JCO-24-02850. Online ahead of print.PMID: 40053891
The RMS2005 trial, conducted by the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG),…
Childhood, Adolescent and Young Adult Poor-Prognosis Rhabdomyosarcoma.
Wasti AT, Bisogno G, Hladun R, Defachelles AS, Casanova M, Breunis WB, Gatz SA, Schoot RA, Ferrari A, Jenney M, Alaggio R, Davila Fajardo R, Terwisscha van Scheltinga S, Shipley J, Meister MT, R van Rijn R, Anderson J, Sparber-Sauer M, Chisholm JC, Merks JHM.
Rhabdomyosarcoma (RMS) is the most common type of soft tissue cancer in children and young people.…
Implications of Implementing Children's Oncology Group Risk Stratification to Patients With Rhabdomyosarcoma Treated on European Paediatric Soft Tissue Sarcoma Study Group Clinical Trial.
Bisogno G, Minard-Colin V, Haduong J, Zanetti I, Ferrari A, Chisholm J, Heske CM, Hladun R, Jenney M, Merks JHM, Venkatramani R.
Pediatr Blood Cancer. 2025 Feb;72(2):e31436. doi: 10.1002/pbc.31436. Epub 2024 Nov 20.
PMID: 39568171
Rhabdomyosarcoma (RMS) is a type of cancer that primarily affects children, and determining the…
Maintenance therapy for pediatric patients with high-risk Rhabdomyosarcoma: A report of dose reductions and dose omissions on outcome.
Di Carlo D, Lyngsie Hjalgrim L, Coppadoro B, Casanova M , Ferrari A, Minard-Colin V, Merks JHM , Bisogno G, EJC Paediatric Oncology. Volume 5, June 2025, 100221
A clinical trial called RMS2005 studied whether adding a lower-dose, long-term chemotherapy…
Parameningeal Rhabdomyosarcoma: Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 Study.
Schoot RA, Taselaar P, Scarzello G, Kolb F, Coppadoro B, Horst ST, Mandeville H, Ferrari A, Hladun R, Helfre S, Ferman S, Kelsey A, Hol MLF, Devalck C, Ben-Arush M, Orbach D, Chisholm J, Jenney M, Minard-Colin V, Bisogno G, Merks JHM.
Head Neck. 2024 Nov 15. doi: 10.1002/hed.27994. Online ahead of print.
PMID: 39545397
The parameningeal (PM) localization is a known adverse prognostic factor in rhabdomyosarcoma (RMS)…
Prognostic role of bone erosion in orbital RMS: a report from the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG).
Di Carlo D, Fichera G, Minard-Colin V, Coppadoro B, Orbach D, Cameron A, Albiac Ramos M, Ben Arush M, Merks JHM, Bisogno G.
Front Oncol. 2024 Dec 12;14:1497193. doi: 10.3389/fonc.2024.1497193. eCollection 2024.
PMID: 39726711
Orbital rhabdomyosarcoma (RMS) typically remains confined to the orbital cavity and has a favorable…
Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial.
Mandeville HC, Bisogno G, Minard-Colin V, Alaggio R, Ben-Arush M, Chargari C, Coppadoro B, Craigie R, Devalck C, Ferman S, Ferrari A, Glosli H, Alvaro RH, Hol M, Mudry P, Orbach D, Albiac MR, Merks JHM, Jenney MEM.Cancer. 2024 Jul 26. doi: 10.1002/cncr.35497. Online ahead of print.PMID: 39058728
This study evaluated the outcomes of children and young people with localised rhabdomyosarcoma…
Treatment of Pediatric, Adolescent, and Young Adult Patients With Fusion-Positive Alveolar Rhabdomyosarcoma Infiltrating Regional Lymph Nodes in the European CWS-2002P and RMS 2005 Studies and the Soft Tissue Sarcoma Registry.
Heinz AT, Ciuffolotti M, Merks JHM, Schönstein A, Minard-Colin V, Fuchs J, Guillen G, Timmermann B, Vokuhl C, Koscielniak E, Chisholm JC, Sparber-Sauer M, Bisogno G.
Pediatr Blood Cancer. 2024 Dec 10:e31476. doi: 10.1002/pbc.31476. Online ahead of print.
PMID: 39655886
Alveolar rhabdomyosarcoma (ARMS) is a rare and aggressive cancer, particularly when it spreads to…
Reappraisal of prognostic factors used in the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 study for localized rhabdomyosarcoma to optimize risk stratification and generate a prognostic nomogram.
De Salvo GL, Del Bianco P, Minard-Colin V, Chisholm J, Jenney M, Guillen G, Devalck C, Van Rijn R, Shipley J, Orbach D, Kelsey A, Rogers T, Guerin F, Scarzello G, Ferrari A, Cesen Mazic M, Merks JHM, Bisogno G; European Pediatric Soft Tissue Sarcoma Study Group.Cancer. 2024 Jul 1;130(13):2351-2360. doi: 10.1002/cncr.35258. Epub 2024 Feb 24.PMID: 38400828
This study used data from patients enrolled in the EpSSG RMS 2005 study to investigate the role of…
The Impact of Radiation Therapy on Metastatic Rhabdomyosarcoma: Results From the EpSSG MTS 2008 Study
Cameron AL, Mandeville H, Coppadoro B, Periasamy M, Davila Fajardo R, Ferrari A, Gaze MN, Helfre S, Magelssen H, Minard-Colin V, Ramos M, Schoot R, Zanetti I, Bisogno G, Chisholm JC, Merks JHM.
Int J Radiat Oncol Biol Phys. 2024 Sep 1:S0360-3016(24)03318-2. doi: 10.1016/j.ijrobp.2024.08.039. Online ahead of print. PMID: 39222824
Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines.
Dávila Fajardo R, Scarzello G, Gaze MN, Boterberg T, Cameron A, Fuchs J, Guérin F, Hoskin P, Krasin MJ, Kroon P, Magelssen H, Mercke C, Merks JHM, Paulsen F, Pommier P, Ramos M, Rees H, Rogers T, Schmid M, Seitz G, Slater O, Smeulders N, Stenman J, Terwisscha S, Chargari C, Mandeville HC. Radiother Oncol. 2024 Jun;195:110273. doi: 10.1016/j.radonc.2024.110273. Epub 2024 Apr 7.
Indeterminate pulmonary nodules in non‐rhabdomyosarcoma soft tissue sarcoma: A study of the European paediatric Soft Tissue Sarcoma Study Group.
Giraudo C, Schoot R, Cardoen L, Stramare R, Coppadoro B, Bisogno G, Bouhamama A, Brennan B, Brisse HJ, Orbach D, Coma A, Di Paolo PL, Fayard C, McDonald L, Moalla S, Morosi C, Pace E, Tang V, van Noesel M, Ferrari A, van Rijn R. Cancer 2023 Oct 17. doi: 10.1002/cncr.35061. Online ahead of print.
Radiologists should be aware of the classification of indeterminate pulmonary nodules in…
Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee.
van Ewijk R, Chatziantoniou C, Adams M, Bertolini P, Bisogno G, Bouhamama A, Caro-Dominguez P, Charon V, Coma A, Dandis R, Devalck C, De Donno G, Ferrari A, Fiocco M, Gallego S, Giraudo C, Glosli H, Ter Horst SAJ, Jenney M, Klein WM, Leemans A, Leseur J, Mandeville HC, McHugh K, Merks JHM, Minard-Colin V, Moalla S, Morosi C, Orbach D, Ording Muller LS, Pace E, Di Paolo PL, Perruccio K, Quaglietta L, Renard M, van Rijn RR, Ruggiero A, Sirvent SI, De Luca A, Schoot RA. Pediatr Radiol. 2023 Nov;53(12):2539-2551. doi: 10.1007/s00247-023-05745-z. Epub 2023 Sep 8.PMID: 37682330
Frontline and Relapsed Rhabdomyosarcoma (FAR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG).
Chisholm J, Mandeville H, Adams M, Minard-Collin V, Rogers T, Kelsey A, Shipley J, van Rijn RR, de Vries I, van Ewijk R, de Keizer B, Gatz SA, Casanova M, Hjalgrim LL, Firth C, Wheatley K, Kearns P, Liu W, Kirkham A, Rees H, Bisogno G, Wasti A, Wakeling S, Heenen D, Tweddle DA, Merks JHM, Jenney M.Cancers (Basel). 2024 Feb 29;16(5):998. doi: 10.3390/cancers16050998.PMID: 38473359
This review article describes the rationale, design and study questions of the international EpSSG…
Biological Role and Clinical Implications of MYOD1L122R Mutation in Rhabdomyosarcoma.
Di Carlo D, Chisholm J, Kelsey A, Alaggio R, Bisogno G, Minard-Colin V, Jenney M, Dávila Fajardo R, Merks JHM, Shipley JM, Selfe JL
Recent advances have greatly improved our understanding of rhabdomyosarcoma (RMS), a type of cancer,…
