Indeterminate pulmonary nodules at diagnosis in rhabdomyosarcoma; Are they clinically significant? A report from the European paediatric Soft tissue sarcoma Study Group
January 31, 2019 the EpSSG study entitled 'Indeterminate pulmonary nodules at diagnosis in rhabdomyosarcoma; Are they clinically significant? A report from the European paediatric Soft tissue sarcoma Study Group' was published online in Journal of Clinical Oncology. In this study we assessed the clinical value of small lung nodules, not fulfilling the criteria for pulmonary metastases. This was an EpSSG radiology study, conducted in 15 larger centers in the United Kingdom, France, Italy and the Netherlands. We showed that small lung nodules are a frequently encountered diagnostic problem, occurring in over 20% of the patients with otherwise localized rhabdomyosarcoma. More importantly, this study showed that the presence of small lung nodules did not impact survival in patients with otherwise localized rhabdomyosarcoma, treated according to the RMS2005 protocol for localized disease. This study proves that patients with small lung nodules do not require additional chest radiotherapy and/or intensified chemotherapy. These results will be used in the upcoming EpSSG Frontline and Relapsed-RMS study.