14 July 2022
Therapy and prognostic significance of regional lymph node involvement in embryonal rhabdomyosarcoma: a report from the European paediatric Soft tissue sarcoma Study Group
Eur J Cancer 2022 Jun 25;172:119-129. doi: 10.1016/j.ejca.2022.05.033. Online ahead of print.
Rhabdomyosarcoma with node involvement has been considered with a worse prognosis. One hundred and forty-three children with embryonal rhabdomyosarcoma and nodal involvement enrolled in the European pediatric soft tissue sarcoma RMS2005 were analyzed for event free and overall survival and identification of prognostic factors. Most pts had tumors with unfavorable characteristics including parameningeal site in 40%. Five-year event-free survival and overall survival was respectively 65.2% and 70%. The results were similar to the other high risk patients group without node involvement. On univariate analysis, larger tumor, unfavorable site, invasiveness, IRS group III, correlated with worse prognosis. On multivariate analysis, IRS Group remained as the only significant prognostic variable but it does not seem to be a consistent estimator. The role of radiotherapy to nodes has to be reconsidered in a larger prospective study.